glutathione high or low in acetaminopen overdose usmle Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90-95% gets broken down safely by glucuronidation + sulfation → non-toxic stuff you pee out. *The problem 🚨 The PLAB 1 &

The PLAB 1 & UKMLA AKT overdose trap? A patient may look well after paracetamol overdose but liver injury can still be developing. Paracetamol overdose is a high yield toxicology The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Phases 1 and 2 acetaminophen metabolism. Acetaminophen consumed in Download Scientific Diagram

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