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Due to the unique characteristics of individual hospital systems, full ICD-11 implementation remains challenging, which is why our experiments continued to utilize ICD-10

The topical route has the broadest applicability and the longest cosmetic safety record

In this study, we screened from an in-house developed metabolites library and identified MeCbl, an endogenous coenzyme form of vitamin B12, as a potent and specific inhibitor of GSDME without any effects on GSDMD