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Introducing a second agent with a different mechanism can restart progress by circumventing the specific adaptations the body made in response to the first compound

The skin then produces excess melanin in those areas as part of the healing process, resulting in dark spots known as post-inflammatory hyperpigmentation

By blocking ME2 to lower NADPH levels and adding BSO (GSH synthesis inhibitor) to enhance the ROS effect in concert, the oxidative defense barrier of AML cells was successfully broken (113, 157)

Consequently, HIF-1 has been shown to upregulate NQO1 expression in response to stressful events, such as hypoxia