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131,132 The brain is particularly sensitive to OS due to numerous variables, including rapid oxidative energy metabolism (a process through which ROS, which are harmful molecules, are constantly produced), high levels of unsaturated fatty acids (which are vulnerable to lipid peroxidation), and relatively low intrinsic antioxidant capability

In one series of patients with 5-oxoproline associated anion gap metabolic acidosis, renal dysfunction accompanied the diagnosis in 3 out of 4 patients [16]

Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis

Therefore, solubilisation using a denaturant such as urea was required