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Among these, a complex model combining PD-1 deficiency with neonatal thymectomy, leads to a fatal AIH-like hepatitis with ANA-positivity, suggesting a prominent protective role of Tregs in AIH, confirmed by reversion of progression to fatal hepatitis by adoptive transfer of Treg [114]

Previously, a Poisson model (Risk ACE) was developed to estimate an individuals annual clinical event rate based on 220 subjects with 52 clinical events from the HALT-C trial