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Insulin-resistant condition contributes to factor the decreased availability of NO in the endothelium, and it may be caused by reductions in the enzyme endothelial NOS, a lack of substrate or cofactors for endothelial NOS, and alterations in intracellular signaling [34]

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Notably, despite increasing GPx activity, DHS (25 M) treatment did not protect splenic lymphocytes from radiation-induced apoptosis

Hence, awareness of patient stratification and precise drug administration is imperative in any AD drug repurposing undertaking (Sun et al., 2022)