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This tamping down suggests a reduction in the innate immune response, which could leave someone vulnerable to infections after exposure to zearalenone.[ref] Kidney damage: Oral exposure to ochratoxin A from contaminated food is linked to kidney injury

Senescent cells are cells that have permanently halted their cell cycle ('replicative arrest') but resist apoptosissometimes called 'zombie cells.' They accumulate with age in multiple tissues and secrete a pro-inflammatory cocktail called the Senescence-Associated Secretory Phenotype (SASP), containing IL-6, IL-8, MMP-3, MMP-9, TNF-, and other factors that damage surrounding healthy tissue

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It follows that diabetes-related neuroinflammation exacerbates neurodegenerative disease and is an important regulatory mechanism for cognitive dysfunction