glutathione in paracetamol overdose The conjugation of acetaminophen by and cytochrome P450 Most people don't realise this

Most people don't realise this Paracetamol breaks down into a toxic compound called NAPQI. Your liver neutralizes it using glutathione (your body's defense shield). But when you take it too often Massive Acetaminophen Overdose: Are We Giving Enough N acetyl cysteine? St. Joseph's University Medical Center: Emergency Medicine Residency Program Paracetamol poisoning:physiological aspects and management strategies A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010

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