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The generation of oxidative DNA lesions, such as 8-oxoguanine (8-oxoG), is linked to the development of various cancers, including melanoma, while the accumulation of these lesions can compromise genomic stability, leading to mutations and the eventual transformation of normal cells into malignant ones 53

Summarizesthe experimental types, molecular mechanisms (e.g., protein acetylation regulation), and application data of small-molecule drugs/intervention strategies targeting GCN5L across 10 disease categories, providing evidence for precision therapy of related diseases (reference citations are marked in the table)

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doi: 10.3390/pharmaceutics12090802 156 ArrueboMValladaresMGonzlez-FernndezA