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Particularly, from the perspective of pharmacogenetics, six SNPs were associated with efficacy and toxicity profiles

payload-specific) ADC resistance involves multifaceted mechanisms spanning both intrinsic and acquired pathways

Elevated accumulation of AGEs can enhance gut barrier dysfunction, intestinal permeability, and bacterial translocation by stimulating the production and release of proinflammatory cytokines, potentially toxic metabolites and bacterial products, as well as causing intestinal epithelial cell damage, contributing to systemic endotoxemia, inflammation, and multiorgan injury 98

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