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In Drosophila , loss of CLN3 was correlated to increased oxidative stress, whereas CLN3 overexpression conferred resistance against oxidative stress

This faster enzyme breakdown then reduces the amount of enzyme available in each cell

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Ketone bodies are released by the liver via solute carrier 16A (SLC16A) family members 1, 6, and 7 and circulate to extrahepatic tissues where they primarily undergo terminal oxidation (Halestrap, When ketone bodies are delivered to the peripheral organs, -OHB is oxidized back to AcAc by the mitochondrial D--hydroxybutyrate dehydrogenase (Figure 2)