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The change in t was of a similar magnitude to the change in CL: approximately 1.5fold for participants with mild renal impairment, approximately 1.8-fold for participants with moderate renal impairment, and approximately 4.0-fold for participants with severe renal impairment compared with their respective normal-to-match groups

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I think they are very genuine and easy-going so that "regular" folks feel comfortable there

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