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SOD1 maintains intracellular copper levels within a specific range and ensures cell antioxidant capacity, which is maintained without causing excessive oxidative damage

Mater Lett 24, 133138

Also, in vitro studies indicate that the responsiveness of pro-B cells to IL-7 is compromised in aged individuals [355], and IL-7 release from stromal cells in the bone marrow also declines with age [356], leading to reduced pro B-cell proliferation