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The dose of MZP treatment was calculated based on the clinical dose in treating AMD patients using the formula: mouse dose (g/kg) = human dose (g/kg) K m ratio, guided by a previous publication (Nair and Jacob, 2016)

TAGs are hydrolyzed by lipases such as ATGL, hormone-sensitive lipase, and monoacylglycerol lipase, or degraded via lipophagy, the process that delivers LDs to lysosomes for catabolism 51,80,81