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In fact, it is not only tumor microenvironments which can educate immune cells since for instance, the GM-CSF can license murine and human monocytes toward their immunosuppressive phenotypes through the PI3K/AKT/mTOR signaling pathway [90]

However, some studies have shown inadequate levels of copper and manganese in the hippocampus in patients with MTLE and hippocampus sclerosis (MTLS-HS), while iron levels remain unaltered ( In summary, abnormal iron metabolism and distribution in the brain of epileptic patients might be one of the reasons for the occurrence and development of epilepsy

These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia. Another study done in 2000, Neuroprotective antioxidants from marijuana (Laboratory of Cellular and Molecular Regulation, NIMH, 2000) concluded: It was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants

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