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Cell culture and treatment N2a cells (Procell Biological Technology Company, CL0168, China) and HEK293T cells (ATCC, CRL-3216, USA) were purchased and confirmed to be free of mycoplasma contamination

The median duration of exposure to pemetrexed was 7.2 months (range: 1 day to 1.7 years)

Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion