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Research has revealed that abnormal regulation of N6-methyladenosine (m6A) modification in HGSOC cells is closely associated with tumor occurrence and metastasis ( Furthermore, the activation of the mTOR signaling pathway is associated with the upregulation of FANCD2, which may regulate sensitivity to platinum-based drugs by affecting the expression of DNA crosslink repair proteins, thereby influencing drug resistance in HGSOC ( 3.5 Non-coding RNAs In the complex pathogenesis of High-Grade Serous Ovarian Carcinoma (HGSOC), multiple non-coding RNAs (ncRNAs) play crucial regulatory roles ( MicroRNAs (miRNAs) play a crucial role in post-transcriptional regulation by binding to target gene mRNAs, inhibiting their translation or promoting their degradation ( Some lncRNAs promote tumor cell proliferation and metastasis by regulating gene transcription and translation ( circRNA as a novel non-coding RNA, has gradually revealed its functions in High-Grade Serous Ovarian Carcinoma (HGSOC)

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There is a current phase I/II clinical trial (NCT04440358) where the aim is to establish the safety and efficacy of using microbubbles in order to disrupt the BBB in patients with recurrent GBM undergoing intravenous carboplatin therapy