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Studies have shown that NOS knockout aggravates bleomycin (BLM)-induced fibrosis, whereas NO supplementation mitigates tissue damage [82]

Liandi, Case Stud

In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance

The therapy for this ultra-rare disease uses a similar strategy to Intellias liver-targeting treatments for hATTR and HAE: it consists of a Cas12i2 nuclease and guide RNA encapsulated in a lipid nanoparticle (LNP)