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J Bioenerg Biomembr 41(6):469472

By integrating recent advancements in understanding the molecular pathways and highlighting promising therapeutic agents, this review provides a solid foundation for future research

Liver and Brain Dysfunction When oxygen levels drop below 2%, the liver reduces hemoglobin production, leading to hypoxia, impaired energy production, and increased red blood cell (RBC) destruction.76 Chronic liver damage is linked to processing RBC byproducts like hemoglobin, iron, and cholesterol, which accumulate in organs like the liver, pancreas, and bone marrow, disrupting metabolism

These patients should be considered for specific treatment (discussed below )