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Case 5: Repeated Supratherapuetic Ingestion A 38-year-old male presents with a toothache for the past 3 days

Mitter, S

Mechanisms that inhibit propagation of the DNA damage signal to the apoptotic machinery include loss of damage recognition, overexpression of HER-2/neu, activation of the PI3-K/Akt (also known as PI3-K/PKB) pathway, loss of p53 function, overexpression of antiapoptotic bcl-2, and interference in caspase activation