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4025-A COMBINATION OF RADIATION THERAPY IMPROVE EFFICACY OF ATEZOLIZUMAB PLUS BEVACIZUMAB (ATE+BEVA) THERAPY IN ADVANCED HEPATOCELLULAR CARCINOMA WITH HIGH RISK FACTOR (HUGE TUMOR, BILIARY AND MAIN PORTAL VEIN INVASION) Sangyoun Hwang, Wan Jeon, Hyung Jun Kim, Jung Woo Im, Ki Jeong Jeon and Beom Jin Shim, Dongnam Institute of Radiological & Medical Sciences Background: Atezolizumab plus bevacizumab (Ate+Beva) proved better efficacy compared to sorafenib as a first line systemic therapy for advanced hepatocellular carcinoma (HCC)

Requires medical supervision and use for defined treatment periods

Genetic evidence for the role of uric acid in Parkinsons disease While, as mentioned, UA derives from the metabolism of purine and hence will be influenced by diet, serum UA is primarily related to genetic factors, particularly those associated with UA transport