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Introduction Cancer cachexia is a severe co-morbidity affecting about 5085% of cancer patients, according to cancer type and stage.( Definition of cachexia and similarities/differences with other muscle wasting disorders A clinical consensus ( The global consensus established in 2011 define pre-cachexia as an early phase in which metabolic derangements, such as impaired glucose tolerance and anorexia, are already present, but the weight loss is substantially absent (5%) (Vigano et al., 2017

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By contrast, skeletal muscle metabolites at rest did not significantly differ between the groups