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66,100 Taken together, the coexistence of multiple types of immune cell suggests a complex inflammatory microenvironment in neurofibroma, which could be associated with nerve injury 99 to promote tumorigenesis

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Additionally, akin to the response to increased energy intake, nutrient deprivation has been shown as a potent inducer of p53 signalling in various cell types by upstream cues like AMPK signalling, fatty acids, or DNA damage 24,25,26,27

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