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Mechanistic themes seen in preclinical research In animal and mechanistic work, AOD-9604 has been associated with: Increased lipolysis (breaking down stored fat) Reduced lipogenesis (reducing fat storage) Interactions with -adrenergic pathways in adipose tissue have been discussed as part of its lipolytic signaling profile (OUP Academic) In obese animal models, AOD-9604 has shown reductions in body weight and body fat and changes consistent with increased fat mobilization

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126 (10), s1-42 (2013)

The addition of the glucagon receptor absent from all other approved or late-stage metabolic peptides activates energy expenditure pathways that the GLP-1 and GIP receptors alone do not reach