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Some patients require slower escalation, extending the optimization period to 3-4 months

The larger concern is using supplements in place of diagnosis when low B12 is tied to GI disease

Coadministration of fluconazole 100 mg PO and hydrochlorothiazide 50 mg PO for 10 days in normal volunteers (n=13) resulted in a significant increase in fluconazole AUC and Cmax compared to fluconazole given alone