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10.1016/s0896-6273(01)00317-8 30 Clinicaltrials.gov (2025)

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For example, LRBA (LPS-responsive and beige-like anchor protein) deficiency, CD25 (IL-2R) deficiency, and gain-of-function mutations in STAT3 all impair Treg cell development, stability, or suppressive function, and result in syndromes marked by multi-organ autoimmunity ( Mouse models have recapitulated many of these mechanisms