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Homocysteine elevation is associated with increased inflammation and decreased blood flow in the brain and retina, causing small vessel disease of the central nervous system (CNS), increased VEGF secretion, endothelial dysfunction, proliferative and non-proliferative retinopathy, as well as diabetic macular edema [126, 129, 228,229,230,231,232]

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Many researchers on the retatrutide dose schedule find that eating 4 to 5 smaller meals works better than 2 to 3 larger ones