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Severe multisystem symptoms require specialist evaluation Seizures, metabolic strokes, severe weakness, cardiomyopathy, developmental regression, exercise-induced rhabdomyolysis, lactic acidosis, major hearing or vision loss and strong maternal inheritance patterns may require neurological, metabolic or genetic evaluation

The affinity of the GHK tripeptide for copper is exceptionally high, and it is this complex that is believed to be the primary biologically active form

Future investigations warrant substantially larger sample sizes to increase power to detect potentially clinically relevant differences, especially in pediatric subjects

1996, 44.Zhai H., Leow Y.-H., Maibach H