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Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling

Methods: Participants from 10 Oral Substitution Treatment (OST) and 8 Targeted Intervention (TI) sites were enlisted for the study

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withaferin A) have been widely studied and found to possess strong free radical scavenging properties, and significantly reduce lipid peroxidation, increase levels of the superoxide dismutase, catalase, glutathione peroxidase, and ascorbic acid activity, as well as enhance levels of interferon-, interleukin-2, and the activity of macrophages to destroy pathogens