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Description

In the macro-vasculature, OS accelerates atherosclerosis by promoting LDL oxidation, macrophage foam cell formation, and plaque instability via matrix metalloproteinase (MMP) activation (Kowluru and Mishra, 2017), while in diabetic nephropathy, podocyte injury results from NOX4-derived O 2 and mitochondrial ROS-mediated apoptosis (Jha et al., 2024)