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Lack of Nrf2 can increase the sensitivity and severity of different respiratory conditions such as BPD, adult respiratory distress syndrome, chronic obstructive pulmonary disease, asthma, and lung cancer, whereas activation of Nrf2 protects against various respiratory diseases (47)

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The medication should be injected subcutaneously into fatty tissue of the abdomen, thigh, or upper arm, with the abdomen often being preferred due to consistent absorption and ease of access

Ultimately, P4HB-K311la exacerbates cardiac injury in RIHD through the PTGS2/SH3GLB1/NDP52 pathway, worsening RIHD progression