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Mitapivat ameliorates 4

Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice

The GLO-1 promoter region contains multiple regulatory elements that allow transcription factors like AP-2, AP-1, Nrf2, E2F4, and NF-B to enhance its activity, leading to increased GLO-1 expression