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Other poor predictors of outcome are old age, female sex, high AST

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An increase in DIO3 activity can also be observed in consumptive hypothyroidism syndrome (associated with tumours such as hepatic hemangioendotheliomas, gliomas, neuroblastomas, colon carcinomas, gastrointestinal stromal tumours, and fibrous tumours), gestational hypothyroidism and treatments with oestrogens