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Gut 55 , 469477 (2006)

Interestingly, MEG3 levels were significantly increased in the Gsp-mutated group compared to the non-mutated one, and determined a reduction in tumor proliferation and invasiveness

This process is also known as cell turnover

Therefore, it is impossible to determine if IN GHK-Cu actually restored the aged hippocampus to a youthful transcriptomic state, or if it pushed the tissue into a novel, alternative compensatory state that simply happens to function better