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(iii) The linear exchange function slope

doi: 10.1016/j.jhep.2019.06.021 4 de VriesMWesterinkJKaasjagerKde ValkHW

Pharmacokinetic data from the trial suggested that administering carboplatin before olaparib may be the preferred treatment schedule to enhance the overall clinical benefit of this combination therapy, as pre-exposure to carboplatin causes intracellular accumulation of olaparib ( P = 0.013), thereby improving its effective availability within tumour cells