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Moreover, because of its high cost, time-consuming process, and difficulty in testing through randomized clinical trials, the application of this therapy is currently limited [216]

First, SFN stands as a exemplary multi-targeted agent whose pleiotropic mechanismsspanning epigenetic regulation, induction of specialized cell death programs, immunomodulation, and CSC targetingprovide a robust foundation for its efficacy against heterogeneous and treatment-resistant malignancies

The term potentiation is also used to describe only the activity of both substances and is applied simultaneously (Dawood et al., 2020

However, our data corresponds with our earlier study in which greater ovary activation was not observed in queens inseminated with semen as compared to queens inseminated with saline solution, but greater insemination volumes resulted in greater ovary activation 41