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Indeed, increased levels of lactate in the TME trigger several pro-tumoral events: i

doi: 10.1186/s13620-021-00192-4 2 AbdelrahmanM

Notably, taking the enrichment ratio and p value into consideration, the most significant biological pathway was related to the pentose phosphate pathway, as the first-line defense against oxidative stress and is critical to cell proliferation, survival, and senescence