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1m) and the increased hepatic oxalate (Fig

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In the liver, iron accumulation in pathological states such as hemochromatosis has been shown to trigger gluconeogenesis, impacting glucose levels ( In preclinical models of non-alcoholic steatohepatitis (NASH), ferroptosis is associated with the development of hepatic inflammation, while inhibition of ferroptosis may protect against NASH progression ( Adipocytes also play a crucial role in the association between ferroptosis and diabetes through several mechanism

These conditions often result in a higher toxic load in the body, which can overwhelm the livers ability to detoxify efficiently