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J Geriatr Cardiol 2015;12:410-6.PubMedPMC 75

On the other hand, through IV therapy, vitamin C is fully absorbed into the bloodstream, allowing for doses 30-70 times higher than oral intake

For recreational fitness enthusiasts who are not subject to drug testing, this restriction does not apply, but it is worth knowing

A 2025 systematic review in the International Journal of Dermatology documented liver function abnormalities in approximately half of IV-treated participants at high doses, which is why DermaVue restricts treatment to evidence-based clinical doses of 400 to 1200 mg with mandatory hepatic monitoring