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(2011) reported higher resilience to APAP in HepG2

Andrology 8 , 15061511 (2020)

The Dihexa group performed significantly better than untreated controls

The pathophysiologic mechanisms underpinning S-AKI are complex, and recent studies have shown that acute tubular necrosis, oxidative stress (7), mitochondrial dysfunction, inflammatory responses (8), microvascular dysfunction (9), and ischemia are involved (Figure 1)