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& Ziebuhr, J

the mechanisms exploited involve interventions on the RAS system [angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs)], vasodilation induced by direct vasodilators [calcium channel blockers (CCBs) such as dihydropyridine], the reduction in atrioventricular conduction (beta-blockers, CCBs such as phenylalkylamine, benzothiazepine), or diuretic actions capable of reducing electrolyte levels, particularly Na + (including loop diuretics, thiazides, and potassium sparing)

Guo F et al

The NEJM June 2026 randomized controlled trial enrolled 1,000 adults with septic shock across Australia and New Zealand Two Hours of Sleep Only Restored One of Four Cognitive Domains