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Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion

Carmel R (2000) Current concepts in cobalamin deficiency

Understanding this is the foundation for understanding why dosing is not a one-size-fits-all figure: the molecule behaves differently from the compounds people often group it with

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