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Graphical abstract Similar content being viewed by others The importance of autophagy in cell homeostasis Autophagy and the ubiquitin proteasome system (UPS) are two major intracellular degradative mechanisms that mediate the catabolism of proteins and organelles

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For example, prohibitin 1 (PHB1) is a ubiquitous protein expressed in multiple subcellular regions but primarily in the inner mitochondrial membrane

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