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Besides, the G2/M cell cycle arrest resulting from modulation of p27, Cyclin B1, and Cyclin E impairs growth and enhances cell death

Flavin autofluorescence is significantly quenched by binding to proteins

The characteristic hypermethylation within promoter regions of colorectal cancer tumor suppressor genes indicates that the epigenome likely plays a key role in mediating non-genetic sequence modifications driving malignant phenotype (182)