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The analysis typically considers four factors: the physical and chemical characterization of the substance, any safety issues raised by using the substance in compounding, the available evidence of effectiveness for the use, and historical use of the substance in compounding, including the medical condition being treated and any references in the medical literature

PLoS ONE 10(4):e0124448 Al-Horani RA, Kar S (2020) Factor XIIIa inhibitors as potential novel drugs for venous thromboembolism

Cell 22 , 731740 (2006)

This type of structure is highly unusual, and, until recently, there was a lack of molecules that closely mimic this motif