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TSHR autoantibodies also underlie Graves orbitopathy (GO) and pretibial myxoedema

Eicosanoids are bioactive lipid mediators derived from oxygenated polyunsaturated fatty acids

A review by Cardinali highlights melatonins potential in counteracting neurodegeneration and frailty in the elderly, noting melatonins excellent safety profile and low toxicity even at high doses ( Melatonin supplementation in older adults must be timed correctly to avoid phase shifts that could worsen circadian timing if misused