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PLoS Comput Biol 13 , e1005752 (2017)

doi: 10.3389/fnsys.2025.1502589 Received 27 September 2024 Accepted 28 February 2025 Published 21 March 2025 Volume 19 - 2025 Edited by Marco Cavagli, Polytechnic University of Turin, Italy Reviewed by Richard H

acidophilus produces SCFAs like acetate, which activate Intercellular adhesion molecule-3-Grabbing Non-integrin Receptor 3 (SIGNR3) receptor on dendritic cells, suppressing IL-6/STAT3 and RORt pathways to inhibit Th17 differentiation while promoting Treg expansion, helping restore immune balance ( L.plantarum and A.muciniphila secrete metabolites that bind TLR2, downregulating NF-B to block the IL-23/Th17 axis, Additionally, A

Gao Y, Pagnon J, Feng HC, Konstantopolous N, Jowett JB, Walder K, Collier GR (2007) Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells