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J Pharm Pharmacol 44(9):761765 Yukawa E, Honda T, Ohdo S, Higuchi S, Aoyama T (1997) Population-based investigation of relative clearance of digoxin in Japanese patients by multiple trough screen analysis: an update

The efficacy and safety of the treatment with different combinations versus treatment with either agent alone has been investigated by different groups in large mulitcentral trials [95, 96]

First, ensuring clinical safety and efficacy remains a major hurdle

The prevailing research view is that a dynamic imbalance between pro-inflammatory and anti-inflammatory cytokines may contribute to the pathogenesis of schizophrenia and subsequent psychopathological symptoms (193196)