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Figure 12A, B shows a significant decline in the anti-apoptotic protein Bcl-2 and a notable increase in the proapoptotic protein Bax

Assuming an average bioavailability of natural folates in a mixed diet of about 50%, it is very likely that 100 g of the biofortified rice grains can satisfy the daily folate requirement for an average adult person or at least supply most of it 812

Lin X, Tascilar M, Lee WH, Vles WJ, Lee BH, Veeraswamy R, Asgari K, Freije D, van Rees B, Gage WR, Bova GS, Isaacs WB, Brooks JD, DeWeese TL, De Marzo AM and Nelson WG

Collectively, the synergistic action of AGE-RAGE signaling, metabolic rewiring, and oxidative stress in the DW microenvironment creates a powerful, self-reinforcing circuit that locks macrophages into a persistent M1 state, thereby perpetuating chronic inflammation and impeding the resolution of healing (Figure 3)