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Nature 349 (6304), 7779

126 In an ALD mouse model, combined Lactobacillus rhamnosus GG and metformin treatment corrected immune response dysregulation by enhancing the gut microbiome, restoring mucosal barrier integrity, regulating immune function, and reducing liver injury, thereby improving ALD

Inclusion criteria - Male and female individuals of at least 60 years of age at the time of the screening visit - Diagnosis of mild cognitive impairment (31) or dementia (32) due to AD according to NIA-AA 2011 criteria - Standardized mini-mental state examination score of at least 18 at the time of the screening visit - Living in a community setting without continuous nursing care - Can identify a reliable study partner with whom they have at least 3 weekly interactions to oversee study drug administration and participate in all clinic visits and some study procedures (including Cognitive Dementia Rating)

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